Stäubli U, Baudry M, Lynch G
Behav Neural Biol. 1984 Jan;40(1):58-69. doi: 10.1016/s0163-1047(84)90170-5.
The effects of chronic intraventricular infusion of leupeptin, a potent inhibitor of thiol proteinases, were tested on ingestive behaviors, escape and avoidance conditioning, and spatial memory in rats. The drug did not detectably influence feeding, drinking, body temperature, or the latency to escape from a mild footshock or inhibitory avoidance behavior. However, rats treated with leupeptin made numerous errors ( reentries ) in an eight-arm spatial maze. These results are interpreted as supporting the hypothesis that calcium-activated thiol proteinases are involved in the formation of certain types of memory.
在大鼠中，测试了慢性脑室内注入亮抑酶肽（一种巯基蛋白酶的强效抑制剂）对摄食行为、逃避和回避条件反射以及空间记忆的影响。该药物未对进食、饮水、体温或从轻度足部电击逃脱的潜伏期或抑制性回避行为产生明显影响。然而，用亮抑酶肽处理的大鼠在八臂空间迷宫中犯了许多错误（重新进入）。这些结果被解释为支持钙激活的巯基蛋白酶参与某些类型记忆形成的假说。
