Gragoudas E S, Goitein M, Seddon J, Verhey L, Munzenrider J, Urie M, Suit H D, Blitzer P, Johnson K N, Koehler A
Br J Ophthalmol. 1984 Jul;68(7):479-85. doi: 10.1136/bjo.68.7.479.
Proton beam irradiation has been used for the treatment of 60 eyes with choroidal melanomas located 3 mm or less from the fovea. The average follow-up period was 18 months. 86% of the treated lesions showed regression at the time of this analysis, and the 14% that did not were followed up for less than a year. Visual acuity remained the same in 47% of the treated eyes, improved in 20%, and deteriorated in 33%. 58% of the treated eyes had visual acuity of 20/100 or better at the last follow-up examination. Radiation vasculopathy with macular oedema was the most common complication, and it was observed in 22% of the treated eyes. These preliminary observations suggest that proton beam irradiation may be a reasonable alternative to enucleation even for this group of choroidal melanomas, which is considered unfavourable in respect of the preservation of visual function.
质子束照射已用于治疗60只距黄斑中心凹3毫米或更近的脉络膜黑色素瘤患者。平均随访期为18个月。在本次分析时，86%的治疗病变显示消退，未消退的14%随访时间不到一年。47%的治疗眼视力保持不变，20%有所改善，33%有所恶化。在最后一次随访检查时，58%的治疗眼视力为20/100或更好。伴有黄斑水肿的放射性血管病变是最常见的并发症，在22%的治疗眼中观察到。这些初步观察结果表明，即使对于这组在视觉功能保留方面被认为不利的脉络膜黑色素瘤，质子束照射也可能是眼球摘除术的合理替代方法。
