Gragoudas E S, Zakov N Z, Albert D M, Constable I J
Arch Ophthalmol. 1979 Nov;97(11):2184-91. doi: 10.1001/archopht.1979.01020020502020.
Fifteen owl monkeys (30 eyes) that received proton irradiation of discrete areas of the retina and choroid have been observed for 3 1/2 years or more after irradiation. The dose delivered to the retina varied from a single dose of 1,600 to 4,750 proton rads and from 10,250 to 18,250 rads delivered in five fractions over a period of one month. Fundus examination, fluorescein angiography, and light and electron microscopy revealed chorioretinal changes at the area of irradiation. The part of the retina adjacent to the chorioretinal scar showed preservation of normal retinal vascular architecture on trypsin digest studies of the retina and on electron microscopic examination, even 1 mm from the edge of the scar. The results of this study suggest that proton beam irradiation may markedly reduce delayed ocular complications, especially radiation retinopathy, which is common to other forms of radiotherapy in the treatment of intraocular tumors.
对15只接受视网膜和脉络膜离散区域质子照射的夜猴（30只眼）在照射后进行了3年半或更长时间的观察。视网膜接受的剂量从单次1600至4750质子拉德到在一个月内分五次给予的10250至18250拉德不等。眼底检查、荧光素血管造影以及光镜和电镜检查显示照射区域出现脉络膜视网膜改变。在对视网膜进行胰蛋白酶消化研究以及电镜检查时，即使在距脉络膜视网膜瘢痕边缘1毫米处，与脉络膜视网膜瘢痕相邻的视网膜部分仍显示正常视网膜血管结构得以保留。本研究结果表明，质子束照射可能显著减少延迟性眼部并发症，尤其是放射性视网膜病变，而放射性视网膜病变在眼内肿瘤的其他放疗形式中很常见。
