Asakura M, Tsukamoto T, Hasegawa K
Brain Res. 1982 Mar 4;235(1):192-7. doi: 10.1016/0006-8993(82)90212-8.
After 7 days of treatment with a variety of antidepressant drugs (desipramine, imipramine, clomipramine, nortriptyline, nialamide), both an increase in alpha 2-receptor density and a decrease in beta-receptor density were observed in the cerebral cortex but not limbic forebrain. However, mianserin caused a marked increase in alpha 2-receptors without any change in beta-receptors. Nisoxetine did not produce any change in these two adrenergic receptors. It is suggested that intrasynaptic norepinephrine is important but that, in addition, other factors may be involved in the increase in alpha 2-receptors induced by antidepressant drugs.
在用多种抗抑郁药物（地昔帕明、丙咪嗪、氯米帕明、去甲替林、尼亚酰胺）治疗7天后，在大脑皮层观察到α2受体密度增加和β受体密度降低，但边缘前脑未出现这种情况。然而，米安色林使α2受体显著增加，而β受体无任何变化。尼索西汀对这两种肾上腺素能受体未产生任何变化。这表明突触内去甲肾上腺素很重要，但此外，其他因素可能也参与了抗抑郁药物诱导的α2受体增加。
