Autrup H, Harris C C, Wu S M, Bao L Y, Pei X F, Lu S, Sun T T, Hsia C C
Chem Biol Interact. 1984 Jun;50(1):15-25. doi: 10.1016/0009-2797(84)90128-5.
Cultured fetal human stomach, esophagus and liver activated benzo[a]pyrene (BP), aflatoxin B1 (AFB) and certain N-nitrosamines into metabolites that bound to cellular DNA. When the 3 organs were compared the highest level of activity was observed in the stomach. The interindividual variation was 10-fold and the amount of carcinogen-DNA adducts did not correlate with the sex or age of the fetus. The reaction products between BP or AFB and cellular DNA were investigated in liver explants. The carcinogen-DNA adduct patterns were identical to those observed in adult human tissues; BPDEI-Gua being the major adduct formed by BP and 2,3-dihydro-2-(7'-guanyl)-3-hydroxy-AFB by AFB. The results indicate that fetal organs can metabolize those oncogenic compounds at an early stage of the development, and that the metabolic pathways and DNA adducts are quite similar to those in experimental animals in which the compounds are carcinogenic.
培养的人胎儿胃、食管和肝脏可将苯并[a]芘（BP）、黄曲霉毒素B1（AFB）和某些N-亚硝胺激活为与细胞DNA结合的代谢产物。当对这三个器官进行比较时，发现胃中的活性水平最高。个体间差异为10倍，致癌物-DNA加合物的量与胎儿的性别或年龄无关。在肝外植体中研究了BP或AFB与细胞DNA之间的反应产物。致癌物-DNA加合物模式与在成人组织中观察到的相同；BPDEI-Gua是BP形成的主要加合物，2,3-二氢-2-（7'-鸟嘌呤基）-3-羟基-AFB是AFB形成的主要加合物。结果表明，胎儿器官在发育早期就能代谢这些致癌化合物，并且代谢途径和DNA加合物与化合物具有致癌性的实验动物中的非常相似。
