Berman R F, Lee J A, Olson K L, Goldman M S
Drug Alcohol Depend. 1984 May;13(3):245-54. doi: 10.1016/0376-8716(84)90065-6.
Adult male Long-Evans rats were maintained on an ethanol-containing liquid diet. During development of ethanol dependence, the rats were given daily i.p. injections of either naloxone (2 mg/kg) or saline daily. At the beginning of ethanol withdrawal, the rats were injected with either naloxone (10 mg/kg) or saline i.p. Rats injected with naloxone during the development of ethanol dependence consumed significantly more of the ethanol diet and therefore more ethanol than rats injected with saline. Rats treated with naloxone throughout both the development of ethanol dependence and during ethanol-withdrawal showed delayed or reduced withdrawal symptomatology compared to rats injected with only saline, naloxone only during the development of dependence and naloxone only during ethanol withdrawal. These results indicate that naloxone can alter the effects of chronic ethanol exposure and further suggest that ethanol may exert some of its actions via the brain opioid system.
成年雄性Long-Evans大鼠维持含乙醇的液体饮食。在乙醇依赖形成过程中，每日给大鼠腹腔注射纳洛酮（2毫克/千克）或生理盐水。在乙醇戒断开始时，给大鼠腹腔注射纳洛酮（10毫克/千克）或生理盐水。在乙醇依赖形成过程中注射纳洛酮的大鼠比注射生理盐水的大鼠消耗的乙醇饮食显著更多，因此摄入的乙醇也更多。与仅注射生理盐水、仅在依赖形成过程中注射纳洛酮以及仅在乙醇戒断期间注射纳洛酮的大鼠相比，在乙醇依赖形成过程和乙醇戒断期间都用纳洛酮治疗的大鼠戒断症状出现延迟或减轻。这些结果表明纳洛酮可以改变慢性乙醇暴露的影响，并进一步表明乙醇可能通过脑阿片系统发挥其某些作用。
