Loven D P, Guernsey D L, Oberley L W
Int J Cancer. 1984 Jun 15;33(6):783-6. doi: 10.1002/ijc.2910330612.
A human, aging lung fibroblast cell strain manifested both copper-zinc superoxide dismutase activity (CuZn-SOD) and manganese-containing superoxide dismutase activity (MnSOD), and these activities were found to be modulated by physiological concentrations of thyroid hormone. The immortal cell lines examined, whether normal or malignant, had no MnSOD activity. The immortal normal cell lines examined had CuZnSOD activity which was modulated by thyroid hormone, whereas the immortal malignant cell lines had CuZnSOD activity which was not affected, or not as strongly affected, by the presence of thyroid hormone.
一株人类衰老肺成纤维细胞系同时表现出铜锌超氧化物歧化酶活性（CuZn-SOD）和含锰超氧化物歧化酶活性（MnSOD），并且发现这些活性受到生理浓度甲状腺激素的调节。所检测的永生细胞系，无论正常还是恶性，均无MnSOD活性。所检测的永生正常细胞系具有受甲状腺激素调节的CuZnSOD活性，而永生恶性细胞系的CuZnSOD活性不受甲状腺激素存在的影响，或受其影响程度不那么强烈。
