Koshido Y, Takara M, Kamiryo Y, Yamamoto N, Yasui H, Kojya T, Fujii M, Hashimoto O, Shimizu Y, Jyoko K
Jpn J Antibiot. 1984 Feb;37(2):229-36.
Cefotiam (CTM) was administered in 31 patients before surgery and the concentration of CTM in serum, extirpated prostatic tissue and bladder wall was measured. Additional studies on pharmacokinetic parameters were carried out. The maximum level of serum concentration, following 1 hour intravenous infusion of 1 g, was 54.0 micrograms/ml after 1 hour and T1/2 was 1.16 hours. The maximum level of prostatic tissue was 19.5 micrograms/g and of bladder wall was 29.9 micrograms/g after 1.2 hours and T1/2 was 1.14 hours for both. An appropriate administration method for single use of CTM in the patient of UTI was discussed and 1 hour infusion of 1 g CTM was suggested.
对31例患者在手术前给予头孢替安（CTM），并测定血清、切除的前列腺组织和膀胱壁中CTM的浓度。进行了药代动力学参数的额外研究。静脉输注1g 1小时后，血清浓度最高水平在1小时时为54.0微克/毫升，半衰期为1.16小时。前列腺组织最高水平在1.2小时时为19.5微克/克，膀胱壁为29.9微克/克，两者半衰期均为1.14小时。讨论了CTM在尿路感染患者中单次使用的合适给药方法，并建议输注1g CTM 1小时。
