Goodnight J E, Quagliana J M, Morton D L
J Surg Oncol. 1984 Jul;26(3):198-201. doi: 10.1002/jso.2930260313.
Three patients treated with bilateral subcutaneous mastectomies and implants for fibrocystic disease or carcinoma in situ subsequently developed invasive breast carcinoma. These cases emphasize that subcutaneous mastectomy does not prevent the development of breast cancer. If the circumstances in an individual patient justify prophylactic mastectomy, then the appropriate procedure would seem to be total mastectomy, which would accomplish thorough removal of all breast tissue, the subareolar region, and the nipple. Subcutaneous mastectomy for the patient who is likely to harbor occult invasive disease seems particularly inappropriate. As a means to reduce the risk of breast cancer, the procedure is unproved and must be considered an experimental therapeutic approach.
三名因纤维囊性疾病或原位癌接受双侧皮下乳房切除术并植入假体的患者随后发生了浸润性乳腺癌。这些病例强调皮下乳房切除术不能预防乳腺癌的发生。如果个别患者的情况证明预防性乳房切除术合理，那么合适的手术似乎是全乳房切除术，它能彻底切除所有乳腺组织、乳晕下区域和乳头。对于可能隐匿有浸润性疾病的患者进行皮下乳房切除术似乎特别不合适。作为降低乳腺癌风险的一种手段，该手术未经证实，必须被视为一种实验性治疗方法。
