Morgenstern L, Kaufman P A, Friedman N B
Am J Surg. 1975 Aug;130(2):251-8. doi: 10.1016/0002-9610(75)90379-7.
Five hundred consecutive cases of breast carcinoma were studied to determine the incidence of multicentric lesions in the resected specimens. When residual tumor in juxtaposition to the primary tumor or biopsy cavity is excluded, 41.6 per cent of specimens exhibited multicentric foci of tumor; 31 per cent of such foci were in sectors or quadrants remote from the primary tumor. In more than half of these cases the lymph nodes were uninvolved and cure rate would have been maximal had these multicentric tumor foci been removed. These findings confirm previous similar studies and we consider tylectomy an inappropriate mode of therapy for breast cancer.
对500例连续性乳腺癌病例进行研究，以确定切除标本中多中心性病变的发生率。当排除与原发肿瘤或活检腔相邻的残留肿瘤时，41.6%的标本显示有肿瘤多中心灶；其中31%的病灶位于远离原发肿瘤的扇形区域或象限。在超过半数的这些病例中，淋巴结未受累，若切除这些多中心肿瘤灶，治愈率将达到最高。这些发现证实了以往类似的研究，我们认为局部切除术不是治疗乳腺癌的合适方式。
