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向饱腹的鸽子脑室内注射鸵鸟β-内啡肽会诱发摄食过量,但不会诱发饮水过量。

Intracerebroventricular injection of ostrich beta-endorphin to satiated pigeons induces hyperphagia but not hyperdipsia.

作者信息

Deviche P, Schepers G

出版信息

Peptides. 1984 Jul-Aug;5(4):691-4. doi: 10.1016/0196-9781(84)90008-1.

DOI:10.1016/0196-9781(84)90008-1
PMID:6093072
Abstract

Satiated pigeons received intracerebroventricular injections of either ostrich (0.06, 0.3 and 1.5 nmoles) or human (0.06 and 1.5 nmoles) beta-endorphin, or a control solution, and their consumption of food and water was monitored during the half hour after these treatments. At each administered dose, ostrich beta-endorphin enhanced food without altering water intake. By contrast, human beta-endorphin did not induce any reliable alteration either of feeding or drinking. Together with previous studies performed in pigeons with opiate antagonists, these results suggest that the feeding system of pigeons is modulated by an endorphinergic mechanism. By contrast, no evidence exists so far that such a mechanism operates for controlling drinking, as appears to be the case in mammals.

摘要

给吃饱的鸽子脑室内注射鸵鸟β-内啡肽(0.06、0.3和1.5纳摩尔)或人β-内啡肽(0.06和1.5纳摩尔),或对照溶液,在这些处理后的半小时内监测它们的食物和水消耗量。在每个给药剂量下,鸵鸟β-内啡肽增加了食物摄入量,而不改变水摄入量。相比之下,人β-内啡肽对进食或饮水均未引起任何可靠的改变。结合之前在鸽子身上使用阿片拮抗剂进行的研究,这些结果表明鸽子的进食系统受内啡肽能机制调节。相比之下,目前尚无证据表明这种机制在控制饮水方面起作用,而在哺乳动物中似乎是这样。

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