1型脊髓灰质炎病毒VP1衣壳多肽诱导中和抗体
Induction of neutralizing antibodies by type 1 poliovirus VP1 capsid polypeptide.
作者信息
Crainic R, Blondel B, Horaud F
出版信息
Dev Biol Stand. 1983;55:185-9.
PMID:6329856
Abstract
Sera against purified VP1, VP2, and VP3 poliovirus capsid polypeptides of type 1 poliovirus were prepared in rabbits. Each serum was demonstrated to be specific for the polypeptide against which it was raised by immunoprecipitation with labeled, individualized capsid polypeptides. One of the anti-VP1 sera had a neutralizing capacity against type 1 poliovirus. It was the only one which reacted in immunoprecipitation with D-antigenic infectious particles.
摘要
用1型脊髓灰质炎病毒的纯化VP1、VP2和VP3衣壳多肽在兔体内制备了抗血清。通过用标记的、个体化的衣壳多肽进行免疫沉淀，证明每种血清对其针对产生的多肽具有特异性。一种抗VP1血清对1型脊髓灰质炎病毒具有中和能力。它是唯一一种在免疫沉淀中与D抗原性感染性颗粒发生反应的血清。
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