Jakobsen A, Poulsen H S, Madsen E L, Petersen S E, Hansen H S
Acta Radiol Oncol. 1984;23(2-3):103-7. doi: 10.3109/02841868409135997.
The ploidy level was investigated by flow cytometric analysis in 143 cases of invasive intraductal mammary carcinoma. Aneuploidy was found in 70% of the tumours. Comparison of ploidy level with histopathologic features, hormone receptor status and clinical characteristics indicated that aneuploid tumours were mostly poorly differentiated (grade III) and oestrogen receptor negative (p less than 0.05). However, this applied only to postmenopausal patients. No correlation appeared between the progesterone receptor status and the ploidy level, but this parameter tended to predict the frequency of lymph node metastases. The possible prognostic significance of these findings is discussed.
通过流式细胞术分析对143例浸润性乳腺导管癌患者的倍体水平进行了研究。70%的肿瘤中发现了非整倍体。对倍体水平与组织病理学特征、激素受体状态及临床特征进行比较，结果表明非整倍体肿瘤大多分化不良（Ⅲ级）且雌激素受体阴性（P<0.05）。然而，这仅适用于绝经后患者。孕激素受体状态与倍体水平之间未发现相关性，但该参数倾向于预测淋巴结转移的频率。讨论了这些发现可能的预后意义。
