氧自由基介导对培养的关节软骨中蛋白聚糖合成的抑制作用。
Oxygen free-radicals mediate an inhibition of proteoglycan synthesis in cultured articular cartilage.
作者信息
Bates E J, Lowther D A, Handley C J
出版信息
Ann Rheum Dis. 1984 Jun;43(3):462-9. doi: 10.1136/ard.43.3.462.
Abstract
Superoxide radical, generated enzymatically by the action of xanthine oxidase on hypoxanthine, significantly inhibited proteoglycan synthesis by cultured bovine articular cartilage. This inhibition was not due to the generation of uric acid or to the generation of superoxide per se. It was immediate in onset and still evident after six days in culture. The inhibition was similar for both 35S-sulphate and 3H-acetate incorporation into glycosaminoglycans and could not be reversed by addition of beta-D-benzyl xyloside. Protein synthesis was also inhibited.
摘要
通过黄嘌呤氧化酶对次黄嘌呤的作用酶促产生的超氧阴离子自由基，显著抑制培养的牛关节软骨蛋白聚糖的合成。这种抑制作用并非由于尿酸的产生或超氧阴离子本身的产生。它在开始时立即出现，并且在培养六天后仍然明显。对于35S-硫酸盐和3H-乙酸盐掺入糖胺聚糖的抑制作用相似，并且不能通过添加β-D-苄基木糖苷来逆转。蛋白质合成也受到抑制。
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本文引用的文献
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Antigen-induced arthritis. Studies on the inhibition of proteoglycan synthesis observed in articular cartilage during short-term joint inflammation.抗原诱导性关节炎。关于短期关节炎症期间关节软骨中蛋白聚糖合成抑制的研究。
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A remarkable increase of superoxide dismutase activity in synovial fluid of patients with rheumatoid arthritis.类风湿性关节炎患者滑液中超氧化物歧化酶活性显著增加。
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