Igari T, Kaneda H, Horiuchi S, Ono S
Clin Orthop Relat Res. 1982 Jan-Feb(162):282-7.
Superoxide dismutase activities in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis were determined by the technique of McCord and Fridovich. The superoxide dismutase activity from the rheumatoid arthritis group was found to be remarkably higher than that from the osteoarthritis group. The high superoxide dismutase activity of rheumatoid arthritis is correlated with the severity of the disease. A significant correlation was also found between C-reactive protein and superoxide dismutase activity. These observations suggest that superoxide dismutase activity is a manifestation of the acute inflammatory stage of rheumatoid arthritis.
采用麦考德和弗里多维奇的技术测定了类风湿性关节炎和骨关节炎患者滑液中的超氧化物歧化酶活性。发现类风湿性关节炎组的超氧化物歧化酶活性明显高于骨关节炎组。类风湿性关节炎中超氧化物歧化酶活性高与疾病的严重程度相关。还发现C反应蛋白与超氧化物歧化酶活性之间存在显著相关性。这些观察结果表明，超氧化物歧化酶活性是类风湿性关节炎急性炎症阶段的一种表现。
