Viticchi C, Gentile S, Piantanelli L
Arch Gerontol Geriatr. 1984 May;3(1):77-82. doi: 10.1016/0167-4943(84)90017-7.
The influence of centrophenoxine treatment on beta-adrenoceptor density has been studied in the brain cortex of old mice. One group of 21-mth-old mice was injected intraperitoneally with 3.8 mg/day centrophenoxine daily for 5 days. A second group received the same daily treatment for 40 days. Two other groups of untreated mice of the same age served as controls. Receptor affinity showed no statistically significant changes in the four different groups investigated. As regards the receptor density, an increasing trend has been elicited between the 5-day treated mice and their controls; however, the increase was not statistically significant. The second group of old mice treated with centrophenoxine for 40 days exhibited a statistically significant increase in receptor density when compared with untreated animals. The modulation of beta-adrenoceptor density may be explained as the result of either a direct action on synaptic structure or an indirect effect mediated by thyroid hormones.
已在老年小鼠的大脑皮层中研究了盐酸甲氯芬酯治疗对β-肾上腺素能受体密度的影响。一组21月龄的小鼠每天腹腔注射3.8毫克盐酸甲氯芬酯，持续5天。另一组接受相同的每日治疗，持续40天。另外两组同龄未治疗的小鼠作为对照。在所研究的四个不同组中，受体亲和力没有统计学上的显著变化。关于受体密度，在接受5天治疗的小鼠与其对照组之间呈现出增加的趋势；然而，这种增加没有统计学意义。与未治疗的动物相比，用盐酸甲氯芬酯治疗40天的第二组老年小鼠的受体密度有统计学上的显著增加。β-肾上腺素能受体密度的调节可能解释为对突触结构的直接作用或由甲状腺激素介导的间接效应的结果。
