Wieacker P, Fey G, Voiculescu I, Ropers H H
Acta Anthropogenet. 1983;7(2):107-12.
By Southern analysis of human-rodent-somatic cell hybrids, the C3 gene could be excluded from the distal portion of the long arm of chromosome 19. In this study, a cloned genomic DNA fragment of the human C3 gene was employed as hybridisation probe. Since C3 is linked with the myotonic dystrophy (DM) and the Lewis (Le) locus, this exclusion may be relevant too for the regional assignment of these and other genes of the large chromosome 19 linkage group.
通过对人-啮齿动物体细胞杂种进行Southern分析，可将C3基因从19号染色体长臂的远端部分排除。在本研究中，使用人C3基因的克隆基因组DNA片段作为杂交探针。由于C3与强直性肌营养不良（DM）和Lewis（Le）基因座连锁，这种排除对于19号大染色体连锁群中这些基因及其他基因的区域定位可能也具有相关性。
