Exclusion of the C3 gene from the 19q133 to 19qter region by Southern analysis of human-rodent somatic cell hybrids, employing a cloned genomic C3 gene fragment.

By Southern analysis of human-rodent-somatic cell hybrids, the C3 gene could be excluded from the distal portion of the long arm of chromosome 19. In this study, a cloned genomic DNA fragment of the human C3 gene was employed as hybridisation probe. Since C3 is linked with the myotonic dystrophy (DM) and the Lewis (Le) locus, this exclusion may be relevant too for the regional assignment of these and other genes of the large chromosome 19 linkage group.