Wells R G, Mohandas T K, Hediger M A
Renal Division, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Genomics. 1993 Sep;17(3):787-9. doi: 10.1006/geno.1993.1411.
The chromosomal location of the gene SGLT2, which is presumed to encode a low-affinity Na+/glucose cotransporter, has been determined using a panel of rodent-human somatic cell hybrids. Southern blot analysis of genomic DNA from 16 different hybrids shows that SGLT2 is located on chromosome 16. Analysis of three additional hybrids that selectively retain all or part of human chromosome 16 demonstrates that SGLT2 is located close to the centromere in band p11.2 of the chromosome.
推测编码低亲和力钠/葡萄糖协同转运蛋白的基因SGLT2的染色体定位已通过一组啮齿动物-人类体细胞杂种确定。对来自16种不同杂种的基因组DNA进行的Southern印迹分析表明，SGLT2位于16号染色体上。对另外三个选择性保留全部或部分人类16号染色体的杂种的分析表明，SGLT2位于该染色体p11.2带的着丝粒附近。
