Platt J, Jones R A, Bucknall R A
Br J Surg. 1984 Aug;71(8):626-8. doi: 10.1002/bjs.1800710822.
A model of bacterial peritonitis, using mice infected with Escherichia coli, has been used to assess the protective effects of intraperitoneal treatment with antiseptics. Of the five antiseptics tested, only chlorhexidine gluconate had any protective effect, concentrations of 0.05 and 0.02 per cent reducing the mortality to 14 and 50 per cent respectively. The other antiseptics, taurolin, noxytiolin, povidone iodine and hypochlorite were all ineffective. Delayed treatment with chlorhexidine was not as effective as instillation immediately postinfection.
一种利用感染大肠杆菌的小鼠建立的细菌性腹膜炎模型，已被用于评估腹腔内使用防腐剂治疗的保护作用。在所测试的五种防腐剂中，只有葡萄糖酸洗必泰有任何保护作用，0.05%和0.02%的浓度分别将死亡率降低至14%和50%。其他防腐剂，如托罗林、诺西替林、聚维酮碘和次氯酸盐均无效。洗必泰延迟治疗不如感染后立即滴注有效。
