Simpson L L
Brain Res. 1984 Jul 2;305(1):177-80. doi: 10.1016/0006-8993(84)91136-3.
The binding fragment of tetanus toxin (50,000 dalton carboxy-terminus of heavy chain) does not block neuromuscular transmission, but it does antagonize the ability of native tetanus toxin to block neuromuscular transmission. The binding fragment of tetanus toxin also antagonizes certain botulinum toxins, including types C and E. Antagonism is at the cell surface, suggesting that the various molecules compete for a similar membrane binding site. The data indicate that the binding site is specific for botulinum toxin rather than tetanus toxin.
破伤风毒素的结合片段（重链50,000道尔顿的羧基末端）并不阻断神经肌肉传递，但它确实拮抗天然破伤风毒素阻断神经肌肉传递的能力。破伤风毒素的结合片段还拮抗某些肉毒杆菌毒素，包括C型和E型。拮抗作用发生在细胞表面，这表明各种分子竞争类似的膜结合位点。数据表明，该结合位点对肉毒杆菌毒素具有特异性，而非破伤风毒素。
