β地中海贫血患者IgE水平升高：与脾切除术和乙型肝炎病毒感染的相关性
Raised IgE levels in beta-thalassaemia: correlation with splenectomy and hepatitis B virus infection.
作者信息
Vierucci A, de Martino M, Rossi M E, Vullo C, Borgatti L, London W T, Blumberg B S
出版信息
Clin Exp Immunol. 1984 Oct;58(1):199-205.
IgE values obtained in 117 beta-thalassaemia patients were significantly higher than in age matched normal subjects. In 31 patients (26.5%) IgE levels were above 2 s.d. of normal values for age, but the frequency of IgE with reaginic activity was lower in patients (5.1%) than in controls (11.9%). The highest values were observed in splenectomized patients who were also positive for one or more serological markers of hepatitis B virus infection. The increase of IgE levels was directly correlated with the number of years after splenectomy, and patients with biopsy proven chronic liver disease had higher IgE levels than those without evidence of liver damage. On the other hand, IgE levels were not correlated with the number of transfusions, age, IgG, IgA, IgM levels or T cell subsets and mitogen responsiveness. These results show that beta-thalassaemia patients develop elevated IgE levels to which splenectomy and hepatitis B virus infection contribute in a synergistic manner.
117例β地中海贫血患者的IgE值显著高于年龄匹配的正常受试者。31例患者（26.5%）的IgE水平高于同年龄正常范围的2个标准差，但具有反应素活性的IgE在患者中的频率（5.1%）低于对照组（11.9%）。在脾切除且一项或多项乙肝病毒感染血清学标志物呈阳性的患者中观察到最高值。IgE水平的升高与脾切除术后的年数直接相关，经活检证实有慢性肝病的患者IgE水平高于无肝损伤证据的患者。另一方面，IgE水平与输血次数、年龄、IgG、IgA、IgM水平或T细胞亚群及丝裂原反应性无关。这些结果表明，β地中海贫血患者IgE水平升高，脾切除和乙肝病毒感染以协同方式促成了这一情况。
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