纯合子β地中海贫血患者脾切除术前和术后的血清免疫球蛋白浓度
Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.
作者信息
Constantoulakis M, Trichopoulos D, Avgoustaki O, Economidou J
出版信息
J Clin Pathol. 1978 Jun;31(6):546-50. doi: 10.1136/jcp.31.6.546.
Abstract
Serum IgM, IgA, and IgG concentrations were measured in 19 patients suffering from blood-dependent homozygous beta-thalassaemia. The study was prospective and the same patients served as presplenectomy controls. IgG levels rose rapidly and continuously after splenectomy IgA levels also rose but not so sharply. IgM fell to low levelr pattern was found in the cross-sectional part of the study comprising 39 splenectomised and 51 non-splenectomised patients who were tested once.
摘要
对19例依赖输血的纯合子β地中海贫血患者的血清IgM、IgA和IgG浓度进行了测定。该研究为前瞻性研究，同一批患者作为脾切除术前的对照。脾切除术后IgG水平迅速且持续上升，IgA水平也有所上升，但幅度没那么大。IgM降至低水平。在包括39例脾切除患者和51例未行脾切除患者的横断面研究部分，这些患者仅接受了一次检测，发现了这样的模式。
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本文引用的文献
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Risk of severe infection in patients with Hodgkin's disease or lymphoma after diagnostic laparotomy and splenectomy.霍奇金病或淋巴瘤患者诊断性剖腹术和脾切除术后发生严重感染的风险。
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