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纯合子β地中海贫血患者脾切除术前和术后的血清免疫球蛋白浓度

Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.

作者信息

Constantoulakis M, Trichopoulos D, Avgoustaki O, Economidou J

出版信息

J Clin Pathol. 1978 Jun;31(6):546-50. doi: 10.1136/jcp.31.6.546.

DOI:10.1136/jcp.31.6.546
PMID:670410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145343/
Abstract

Serum IgM, IgA, and IgG concentrations were measured in 19 patients suffering from blood-dependent homozygous beta-thalassaemia. The study was prospective and the same patients served as presplenectomy controls. IgG levels rose rapidly and continuously after splenectomy IgA levels also rose but not so sharply. IgM fell to low levelr pattern was found in the cross-sectional part of the study comprising 39 splenectomised and 51 non-splenectomised patients who were tested once.

摘要

对19例依赖输血的纯合子β地中海贫血患者的血清IgM、IgA和IgG浓度进行了测定。该研究为前瞻性研究，同一批患者作为脾切除术前的对照。脾切除术后IgG水平迅速且持续上升，IgA水平也有所上升，但幅度没那么大。IgM降至低水平。在包括39例脾切除患者和51例未行脾切除患者的横断面研究部分，这些患者仅接受了一次检测，发现了这样的模式。

相似文献

1
Serum immunoglobulin concentrations before and after splenectomy in patients with homozygous beta-thalassaemia.纯合子β地中海贫血患者脾切除术前和术后的血清免疫球蛋白浓度
J Clin Pathol. 1978 Jun;31(6):546-50. doi: 10.1136/jcp.31.6.546.
2
Serum immunoglobulins in beta-thalassaemia after splenectomy.脾切除术后β地中海贫血患者的血清免疫球蛋白
Acta Haematol. 1971;46(5):267-70. doi: 10.1159/000208585.
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Serum immunoglobulin levels in children after splenectomy. A prospective study.脾切除术后儿童的血清免疫球蛋白水平。一项前瞻性研究。
Am J Dis Child. 1984 Jan;138(1):53-5.
4
Serum-immunoglobulin levels in thalassaemia and the effects of splenectomy.地中海贫血患者的血清免疫球蛋白水平及脾切除术的影响。
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[Immunoelectrophoretic studies of serum immunoglobulins in children with Cooley's anemia before and after splenectomy and their relation to infectious diseases].[库利贫血患儿脾切除前后血清免疫球蛋白的免疫电泳研究及其与传染病的关系]
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[Changes in the immunoglobulin levels in some patients with Cooley's disease].[部分库利氏贫血患者免疫球蛋白水平的变化]
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Proceedings: Immunoglobulin levels in children with thalassaemia.会议论文：地中海贫血患儿的免疫球蛋白水平
Arch Dis Child. 1973 Oct;48(10):828-9. doi: 10.1136/adc.48.10.828-e.
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Immunoglobulin levels in children with homozygous beta-thalassemia.纯合子β地中海贫血患儿的免疫球蛋白水平
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Immunological profile after splenectomy in children with beta-thalassaemia major.
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引用本文的文献

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Alloimmunization to Red Cells and the Association of Alloantibodies Formation with Splenectomy Among Transfusion-Dependent β-Thalassemia Major/HbE Patients.输血依赖型重型β地中海贫血/HbE患者红细胞同种免疫及同种抗体形成与脾切除术的关联
Indian J Clin Biochem. 2015 Apr;30(2):198-203. doi: 10.1007/s12291-014-0424-6. Epub 2014 Feb 16.
2
Immune functions in splenectomized thalassaemic children.脾切除的地中海贫血患儿的免疫功能
Indian J Pediatr. 2000 Dec;67(12):871-6. doi: 10.1007/BF02723947.
3
Serum immunoglobulins, IgG subclasses, isohemagglutinins and complement-3 levels in patients with thalassemia major.重型地中海贫血患者的血清免疫球蛋白、IgG亚类、同种血凝素和补体3水平。
Indian J Pediatr. 1997 Mar-Apr;64(2):215-9. doi: 10.1007/BF02752450.
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[Alterations of humoral and cellular immunity after splenectomy (author's transl)].脾切除术后体液免疫和细胞免疫的改变（作者译）
Klin Wochenschr. 1981 May 15;59(10):485-93. doi: 10.1007/BF01696210.
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Differential inhibition of the MLR by iron: association with HLA phenotype.铁对混合淋巴细胞反应的差异性抑制：与HLA表型的关联
Immunogenetics. 1981;12(1-2):129-40. doi: 10.1007/BF01561656.
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Immunological abnormalities in thalassaemia major. I. A transfusion-related increase in circulating cytoplasmic immunoglobulin-positive cells.重型地中海贫血的免疫异常。I. 与输血相关的循环细胞质免疫球蛋白阳性细胞增多。
Clin Exp Immunol. 1985 Nov;62(2):397-404.
7
Increased IgM levels associated with splenosis?
Ir J Med Sci. 1987 Jun;156(6):168-71. doi: 10.1007/BF02955199.
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Intradermal hepatitis B vaccine in thalassaemia and sickle cell disease.地中海贫血和镰状细胞病中的皮内注射乙型肝炎疫苗
Arch Dis Child. 1989 Apr;64(4):535-40. doi: 10.1136/adc.64.4.535.

本文引用的文献

1
Postsplenectomy infection in Cooley's anemia. An appraisal of the problem in this and other blood disorders, with a consideration of prophylaxis.库利贫血患者脾切除术后感染。对本病及其他血液疾病中该问题的评估，并对预防措施进行探讨。
N Engl J Med. 1962 Apr 12;266:737-43. doi: 10.1056/NEJM196204122661501.
2
Hazard of overwhelming infection after splenectomy in childhood.儿童脾切除术后暴发性感染的风险
N Engl J Med. 1967 Jun 1;276(22):1225-9. doi: 10.1056/NEJM196706012762203.
3
The hazard of infection following splenectomy in children.
Am J Dis Child. 1968 Jul;116(1):1-12. doi: 10.1001/archpedi.1968.02100020003001.
4
Risk of severe infection in patients with Hodgkin's disease or lymphoma after diagnostic laparotomy and splenectomy.霍奇金病或淋巴瘤患者诊断性剖腹术和脾切除术后发生严重感染的风险。
Ann Intern Med. 1972 Jul;77(1):143-6. doi: 10.7326/0003-4819-77-1-143.
5
Serum immunoglobulins in beta-thalassaemia after splenectomy.脾切除术后β地中海贫血患者的血清免疫球蛋白
Acta Haematol. 1971;46(5):267-70. doi: 10.1159/000208585.
6
Infections after splenectomy.脾切除术后感染。
Ann Intern Med. 1973 May;78(5):780-1. doi: 10.7326/0003-4819-78-5-780_2.
7
Serum immunoglobulin and transferrin levels after childhood splenectomy.儿童脾切除术后的血清免疫球蛋白和转铁蛋白水平。
Arch Dis Child. 1970 Feb;45(239):114-7. doi: 10.1136/adc.45.239.114.
8
Infection and iron overload in thalassemia.地中海贫血中的感染与铁过载
Ann N Y Acad Sci. 1969 Nov 20;165(1):148-55. doi: 10.1111/j.1749-6632.1969.tb27784.x.
9
Frequency of antibodies to various antigenic determinants in polytransfused patients with homozygous thalassaemia in Greece.
Vox Sang. 1971 Mar;20(3):252-8. doi: 10.1111/j.1423-0410.1971.tb00436.x.
10
Serum-immunoglobulin levels in thalassaemia and the effects of splenectomy.地中海贫血患者的血清免疫球蛋白水平及脾切除术的影响。
Lancet. 1971 Jul 31;2(7718):237-9. doi: 10.1016/s0140-6736(71)92573-6.