Johnstone I B
Can Vet J. 1986 Sep;27(9):315-8.
Von Willebrand's disease is the most common inherited bleeding disorder of dogs occurring with particularly high frequency in Doberman pinscher dogs. Because of its method of transmission (autosomal incomplete dominant), the clinical and laboratory severity of the disease varies considerably. "Stress" may be required to make the increased bleeding tendency clinically apparent. This report describes five cases of Von Willebrand's disease in Doberman pinscher dogs and illustrates the variety of clinical expressions that the disease may take.
血管性血友病是犬类最常见的遗传性出血性疾病，在杜宾犬中尤为高发。由于其遗传方式（常染色体不完全显性），该疾病的临床和实验室严重程度差异很大。可能需要“应激”才能使出血倾向增加在临床上显现出来。本报告描述了5例杜宾犬血管性血友病病例，并阐述了该疾病可能呈现的各种临床表现形式。
