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[部分脾切除术后正常小鼠脾脏杀伤细胞活性的动态变化]

[Dynamics of the activity of the normal mouse spleen killers after partial splenectomy].

作者信息

Van'ko L V, Sukhikh G T, Babaeva A G, Iudina N V, Suleĭmanova N S

出版信息

Biull Eksp Biol Med. 1984 Sep;98(9):331-3.

PMID:6333256
Abstract

The activity of natural killers from the mouse spleen was determined by 51Cr clearance from labeled target cells (YAC-1) at different times after resection of the two-thirds of the spleen. In the early periods after operation, there was a decrease in the natural cytotoxic activity of splenocytes followed by a relatively rapid rise for 8 days until the maximum exceeding the cytotoxicity of intact spleen cells was reached. However, the total lytic potential of the regenerating spleen did not return to normal during 28 days.

摘要

通过在切除三分之二脾脏后的不同时间,检测标记靶细胞(YAC-1)中51Cr的清除情况,来测定小鼠脾脏中自然杀伤细胞的活性。术后早期,脾细胞的自然细胞毒性活性下降,随后在8天内相对快速上升,直至达到超过完整脾细胞细胞毒性的最大值。然而,再生脾脏的总裂解潜力在28天内未恢复正常。

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