Pollack M S, Gold J, Metroka C E, Safai B, Dupont B
Hum Immunol. 1984 Oct;11(2):99-103. doi: 10.1016/0198-8859(84)90048-x.
During the past three years, an epidemic of acquired immunodeficiency syndromes (AIDS) involving the presence of specific forms of cancer (notably Kaposi's sarcoma) and infection (e.g., pneumocystis carinii) ordinarily seen only in severely immunosuppressed hosts has occurred among active homosexuals, Haitian immigrants, drug users, and hemophiliacs in large cities in the United States and elsewhere. An as yet unidentified viral agent is presumably the cause of the initial immunodeficiency and host genetic factors may influence the subsequent development of different clinical symptoms in different patients. We have previously reported that the HLA antigens DR5 and DR2 are associated with susceptibility to Kaposi's sarcoma (KS) in different Caucasian subpopulations. We now have also noted that AIDS patients with opportunistic infections have a normal frequency of DR2 and DR5 and a significantly increased frequency of DR3 and that the ultimate clinical expression of AIDS in patients with unexplained lymphadenopathy may depend upon genetic factors associated with these particular DR types.
在过去三年中，在美国及其他地区的大城市里，活跃的同性恋者、海地移民、吸毒者和血友病患者中出现了获得性免疫缺陷综合征（艾滋病）的流行，这些患者身上出现了特定形式的癌症（尤其是卡波西肉瘤）和感染（如卡氏肺囊虫感染），而这些情况通常仅见于严重免疫抑制的宿主。一种尚未明确的病毒因子可能是初始免疫缺陷的病因，宿主遗传因素可能影响不同患者随后出现的不同临床症状。我们之前曾报道，HLA抗原DR5和DR2与不同高加索亚人群对卡波西肉瘤（KS）的易感性相关。我们现在还注意到，患有机会性感染的艾滋病患者DR2和DR5的频率正常，而DR3的频率显著增加，并且原因不明的淋巴结病患者中艾滋病的最终临床表型可能取决于与这些特定DR类型相关的遗传因素。
