撒丁岛的人类白细胞抗原与卡波西肉瘤

HLA and Kaposi's sarcoma in Sardinia.

作者信息

Contu L, Cerimele D, Pintus A, Cottoni F, La Nasa G

出版信息

Tissue Antigens. 1984 Apr;23(4):240-5. doi: 10.1111/j.1399-0039.1984.tb00038.x.

DOI:10.1111/j.1399-0039.1984.tb00038.x

Abstract

Twelve Sardinian patients affected by histologically defined classic Kaposi's sarcoma (KS) were HLA-A, B, C and DR typed. Compared to 220 age and ethnically matched healthy controls, KS patients showed a significant increase in HLA-DR5 (66.6 vs 23.1%, P less than 0.001) and a considerable decrease in HLA-DR3 (8.3 vs 53.6%, P = 0.0055). No definite association was observed for other HLA antigens. These results confirm the existence of an HLA associated genetic control of KS susceptibility and support the hypothesis that HLA-DR5 plays the role of a predisposition marker while HLA-DR3 bears a genetic resistance to the disease.

摘要

对12例经组织学确诊为经典型卡波西肉瘤（KS）的撒丁岛患者进行了HLA - A、B、C和DR分型。与220名年龄和种族匹配的健康对照相比，KS患者的HLA - DR5显著增加（66.6%对23.1%，P小于0.001），而HLA - DR3显著降低（8.3%对53.6%，P = 0.0055）。未观察到其他HLA抗原的明确关联。这些结果证实了存在与HLA相关的KS易感性遗传控制，并支持以下假说：HLA - DR5起易患性标志物的作用，而HLA - DR3对该疾病具有遗传抗性。