HIV-1感染后长期临床无症状进展的特征是MHC处缺乏补体C4无效等位基因。
Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC.
作者信息
Hentges F, Hoffmann A, Oliveira de Araujo F, Hemmer R
机构信息
Department of Immuno-Allergology, Centre Hospitalier de Luxembourg.
出版信息
Clin Exp Immunol. 1992 May;88(2):237-42. doi: 10.1111/j.1365-2249.1992.tb03067.x.
Abstract
The length of time after which persons infected with HIV-1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV-1-infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV-1-infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.
摘要
感染HIV-1的人发展为艾滋病的时间长短不一。已表明MHC的某些等位基因会对HIV-1感染者的临床结局产生负面影响，并与特殊临床表现相关。我们对54名感染HIV-1的白种人进行了MHC I类、II类和III类抗原研究。艾滋病发病前病程较长的个体的MHC谱特征是C4无效等位基因频率较低。
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