Maynard F M, Diokno A C
J Urol. 1984 Nov;132(5):943-6. doi: 10.1016/s0022-5347(17)49959-9.
A total of 50 patients with recent spinal cord injury secondary to trauma participated in a prospective study of urinary complications during an interval of clean intermittent catheterization at initial hospitalization in a spinal cord injury unit. Patients were assigned randomly to groups receiving or not receiving a prophylactic antibacterial preparation. Both groups were divided further into subgroups in which laboratory infections (bacteriuria more than 100,000 organisms per ml.) were treated with definitive antibiotics or in which antibiotic treatment was given only for clinical infections (fever more than 100F or urethral discharge and bacteriuria). Antibacterial prophylaxis significantly reduced the probability of laboratory infection but not the probability of clinical infection, although a trend was noted toward fewer clinical infections. No significant reduction was noted in the probability of clinical infection in subgroups treated promptly for laboratory infection.
共有50例近期因创伤导致脊髓损伤的患者参与了一项前瞻性研究，该研究针对脊髓损伤病房初次住院期间进行间歇性清洁导尿阶段的泌尿系统并发症展开。患者被随机分为接受或不接受预防性抗菌制剂的组。两组又进一步分为亚组，其中实验室感染（每毫升尿中细菌数超过100,000个）用确定性抗生素治疗，或者仅针对临床感染（体温超过100华氏度或尿道分泌物及菌尿）给予抗生素治疗。抗菌预防显著降低了实验室感染的概率，但未降低临床感染的概率，尽管有临床感染减少的趋势。对于实验室感染及时进行治疗的亚组，临床感染概率未显著降低。
