Pearman J W, Bailey M, Harper W E
Department of Microbiology, Royal Perth Hospital, Western Australia.
Br J Urol. 1988 Aug;62(2):140-4. doi: 10.1111/j.1464-410x.1988.tb04293.x.
An open, prospective, randomised, comparative study of "Trisdine" and kanamycin-colistin bladder instillations in reducing significant bacteriuria during intermittent urethral catheterisation was conducted. Trisdine is an aqueous solution of chlorhexidine gluconate 0.01% with added ethylenediaminetetra-acetic acid disodium salt and TRIS buffer at final concentrations of 1.34 mMoles and 0.01 Molar respectively. All patients (15 males and 3 females) admitted with acute spinal cord trauma and bladder involvement requiring intermittent catheterisation for more than 5 days during a 12-month period were studied. There was no significant difference in the mean incidence of significant bacteriuria during intermittent catheterisation in the 7 males who had kanamycin-colistin bladder instillations compared with the 8 males who had Trisdine instillations. A comparison could not be made in the females because there were only 3 patients. Because Trisdine is more stable at ambient temperatures, is less likely to select antibiotic-resistant bacteria and is less expensive, it is concluded that Trisdine is preferable to kanamycin-colistin solution for bladder instillations during intermittent catheterisation.
开展了一项关于“Trisdine”与卡那霉素 - 黏菌素膀胱灌注在减少间歇性尿道插管期间显著菌尿方面的开放性、前瞻性、随机对照研究。Trisdine是一种含0.01%葡萄糖酸洗必泰的水溶液，分别添加了终浓度为1.34毫摩尔和0.01摩尔的乙二胺四乙酸二钠盐和TRIS缓冲液。对12个月期间因急性脊髓损伤并伴有膀胱受累而需要间歇性插管超过5天入院的所有患者（15名男性和3名女性）进行了研究。在接受卡那霉素 - 黏菌素膀胱灌注的7名男性与接受Trisdine灌注的8名男性之间，间歇性插管期间显著菌尿的平均发生率无显著差异。由于女性患者仅有3例，因此无法对女性患者进行比较。鉴于Trisdine在环境温度下更稳定，产生抗生素耐药菌的可能性更小且成本更低，得出结论：在间歇性插管期间进行膀胱灌注时，Trisdine比卡那霉素 - 黏菌素溶液更可取。
