Richards D B, Lipton J M
Peptides. 1984 Jul-Aug;5(4):815-7. doi: 10.1016/0196-9781(84)90027-5.
In previous experiments, alpha-MSH (1-13) and ACTH (1-24), which contains the alpha-MSH 1-13 amino acid sequence, were found to reduce fever after central and peripheral administration of low, non-hypothermic doses. Shorter molecules, including alpha-MSH 1-10, had no effect. The idea that the 11-13 amino acid sequence is important to the effect of the parent molecule was tested by giving lysine-proline-valine both centrally and peripherally to rabbits made febrile by IV administration of leukocytic pyrogen. The tripeptide reduced fever after both central (0.5-2.0 mg) and peripheral (2-200 mg) administration. It appears that the 11-13 sequence is part of the message sequence of alpha-MSH with regard to antipyretic activity. However, the lower potency relative to that of the parent molecule suggests that other portions of the molecule are essential to full expression of the antipyretic effect.
在先前的实验中，发现α-促黑素（1-13）和促肾上腺皮质激素（1-24）（其包含α-促黑素1-13氨基酸序列）在以低的、非低温剂量进行中枢和外周给药后可降低发热。包括α-促黑素1-10在内的较短分子则无此作用。通过向经静脉注射白细胞热原而发热的家兔中枢和外周给予赖氨酸-脯氨酸-缬氨酸，对11-13氨基酸序列对母体分子效应很重要这一观点进行了验证。该三肽在中枢（0.5-2.0毫克）和外周（2-200毫克）给药后均可降低发热。就解热活性而言，11-13序列似乎是α-促黑素信息序列的一部分。然而，相对于母体分子，其效力较低表明该分子的其他部分对于解热作用的充分发挥至关重要。
