Robinson C J, Abraham A A, Balazs T
Clin Exp Immunol. 1984 Nov;58(2):300-6.
Mercuric chloride (HgCl2) was administered parenterally to outbred Swiss ICR mice of both sexes and to inbred A/J male mice. In repeated experiments both male and female ICR mice developed anti-nuclear antibodies (ANA) giving a distinctive nucleolar fluorescence pattern in response to HgCl2 treatment. Within 1 week after the start of treatment, many of the mice had serum ANA of the IgG class directed against nucleolar antigen(s). Maximum ANA induction was reached by week 4. Inbred A/J male mice were resistant to the induction of ANA by HgCl2.
将氯化汞（HgCl2）经非肠道途径给予远交系瑞士ICR雌雄小鼠以及近交系A/J雄性小鼠。在重复实验中，雄性和雌性ICR小鼠在接受HgCl2处理后均产生了抗核抗体（ANA），呈现出独特的核仁荧光模式。在治疗开始后的1周内，许多小鼠血清中出现了针对核仁抗原的IgG类ANA。到第4周时ANA诱导达到最大值。近交系A/J雄性小鼠对HgCl2诱导ANA具有抗性。
