小鼠药物性红斑狼疮的研究。I. 药物诱导的抗核抗体（ANA）
Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA).
作者信息
ten Veen J H, Feltkamp T E
出版信息
Clin Exp Immunol. 1972 Jun;11(2):265-76.
Abstract
Hydralazin, isoniazid, procainamide, α-methyldopa and chlorthalidone were given orally to mice of three inbred strains: BALB/CJ, C57/BL/6J and A/JAX. All drugs significantly increased the frequency of antinuclear antibodies (ANA). The results were most marked after 8 months of treatment. Although a slight preponderance of females was observed for ANA frequencies in BALB/CJ and A/JAX mice, this was significant only for hydralazin- and procainamide-treated animals. C57/BL/6J males appeared to respond better than females. Genetical factors appear of importance in the induciton of drug induced lupus erythematosus (DILE).
摘要
向三种近交系小鼠（BALB/CJ、C57/BL/6J和A/JAX）口服给予肼屈嗪、异烟肼、普鲁卡因胺、α-甲基多巴和氯噻酮。所有药物均显著增加抗核抗体（ANA）的频率。治疗8个月后结果最为明显。虽然在BALB/CJ和A/JAX小鼠中观察到ANA频率在雌性中略有优势，但仅在接受肼屈嗪和普鲁卡因胺治疗的动物中具有统计学意义。C57/BL/6J雄性小鼠似乎比雌性小鼠反应更好。遗传因素在药物性红斑狼疮（DILE）的诱导中似乎很重要。
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