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小鼠药物性红斑狼疮的研究。I. 药物诱导的抗核抗体（ANA）

Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA).

作者信息

ten Veen J H, Feltkamp T E

出版信息

Clin Exp Immunol. 1972 Jun;11(2):265-76.

PMID:4557182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553628/
Abstract

Hydralazin, isoniazid, procainamide, α-methyldopa and chlorthalidone were given orally to mice of three inbred strains: BALB/CJ, C57/BL/6J and A/JAX. All drugs significantly increased the frequency of antinuclear antibodies (ANA). The results were most marked after 8 months of treatment. Although a slight preponderance of females was observed for ANA frequencies in BALB/CJ and A/JAX mice, this was significant only for hydralazin- and procainamide-treated animals. C57/BL/6J males appeared to respond better than females. Genetical factors appear of importance in the induciton of drug induced lupus erythematosus (DILE).

摘要

向三种近交系小鼠（BALB/CJ、C57/BL/6J和A/JAX）口服给予肼屈嗪、异烟肼、普鲁卡因胺、α-甲基多巴和氯噻酮。所有药物均显著增加抗核抗体（ANA）的频率。治疗8个月后结果最为明显。虽然在BALB/CJ和A/JAX小鼠中观察到ANA频率在雌性中略有优势，但仅在接受肼屈嗪和普鲁卡因胺治疗的动物中具有统计学意义。C57/BL/6J雄性小鼠似乎比雌性小鼠反应更好。遗传因素在药物性红斑狼疮（DILE）的诱导中似乎很重要。

相似文献

1
Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA).小鼠药物性红斑狼疮的研究。I. 药物诱导的抗核抗体（ANA）
Clin Exp Immunol. 1972 Jun;11(2):265-76.
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Studies on drug-induced lupus erythematosus in mice. II. Drug-induced smooth muscle and skeletal muscle antibodies.小鼠药物性红斑狼疮的研究。II. 药物诱导的平滑肌和骨骼肌抗体。
Clin Exp Immunol. 1973 Nov;15(3):375-84.
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Antinuclear antibodies.抗核抗体
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[Lupus induced by isoniazid].[异烟肼诱发的狼疮]
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[Lupus erythematosus disseminatus induced by alpha methyldopa].
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Ann Intern Med. 1986 Mar;104(3):310-3. doi: 10.7326/0003-4819-104-3-310.
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Drug-induced antinuclear antibodies and lupus syndromes.药物性抗核抗体与狼疮综合征
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本文引用的文献

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LUPUS DIATHESIS AND THE HYDRALAZINE SYNDROME.狼疮素质与肼苯哒嗪综合征
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EVIDENCE FOR A PREDISPOSITION TO RHEUMATIC DISEASES IN FAMILIES OF PATIENTS DEVELOPING DRUG-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS.药物性系统性红斑狼疮患者家族中存在风湿性疾病易感性的证据。
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Syndrome simulating collagen disease caused by hydralazine (Apresoline).由肼屈嗪（阿普利素灵）引起的类胶原病综合征
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Distribution of antibodies to native DNA, single-stranded DNA, and double-stranded RNA in mouse serums.小鼠血清中针对天然DNA、单链DNA和双链RNA的抗体分布。
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Antibodies to nucleoprotein and to hydrazide-altered soluble nucleoprotein in tuberculous patients receiving isoniazid.接受异烟肼治疗的结核病患者体内针对核蛋白及酰肼修饰的可溶性核蛋白的抗体。
Clin Exp Immunol. 1969 Oct;5(4):429-37.
10
DNA-binding assay for detection of anti-DNA antibodies in NZB-NZW F1 mice.用于检测NZB-NZW F1小鼠中抗DNA抗体的DNA结合试验。
J Immunol. 1969 Mar;102(3):788-90.