全身热疗和卡氮芥对大鼠放射性脊髓炎发展的影响。

Effect of whole body hyperthermia and BCNU on the development of radiation myelitis in the rat.

作者信息

Neville A J, Robins H I, Martin P, Gilchrist K W, Dennis W H, Steeves R A

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Oct;46(4):417-20. doi: 10.1080/09553008414551601.

Abstract

A radiant heat device was used to study the interaction of 41.8 degrees C whole body hyperthermia (WBH), radiation (40 Gy) and the lipophilic anti-neoplastic agent BCNU in the development of myelitis in the rat spinal cord. The addition of WBH and BCNU neither precipitated myelitis acutely nor shortened the latency before the onset of neurological signs in irradiated animals.

摘要

使用一种辐射热装置来研究41.8摄氏度的全身热疗（WBH）、辐射（40 Gy）和亲脂性抗肿瘤药物卡莫司汀（BCNU）在大鼠脊髓脊髓炎发展过程中的相互作用。全身热疗和卡莫司汀的联合使用既不会急性引发脊髓炎，也不会缩短受辐照动物出现神经症状之前的潜伏期。