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[双西芬对正常及受辐照生物体造血和免疫系统的影响]

[The effect of diucifon on the hematopoietic and immune systems in normal and irradiated organisms].

作者信息

Kostiuk L E, Semina O V, Kurilets E S, Poverennyĭ A M, Goloshchapov N M

出版信息

Radiobiologiia. 1984 Sep-Oct;24(5):687-90.

PMID:6334330
Abstract

It was shown that irradiation of mice with the dose of 4 Gy affected the immune and haemopoietic systems. Diucyphone injected on days 6-8 after irradiation favoured the production of antibodies in the spleen, increased the yield of exogenous splenic colonies and corrected differentiation of the haemopoietic stem cells. In the normal body, diucyphone decreased the colony-forming activity and did not change the haemopoietic stem cell differentiation.

摘要

结果表明,用4 Gy剂量照射小鼠会影响其免疫和造血系统。在照射后第6至8天注射双西福林有利于脾脏中抗体的产生,提高外源性脾集落的产量,并纠正造血干细胞的分化。在正常机体中,双西福林会降低集落形成活性,且不会改变造血干细胞的分化。

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[The effect of diucifon on the hematopoietic and immune systems in normal and irradiated organisms].[双西芬对正常及受辐照生物体造血和免疫系统的影响]
Radiobiologiia. 1984 Sep-Oct;24(5):687-90.
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