Ado A D, Dontsov V I
Biull Eksp Biol Med. 1984 Dec;98(12):692-4.
It was shown that B lymphocyte motility activated by anti-immunoglobulin serum may be abrogated in a Na+-deficient medium and in a 10(-5)M trifluoperazine-containing medium but not in a Ca2+-deficient medium. The tetracycline fluorescence test demonstrated Ca2+ efflux from isolated B lymphocyte mitochondria due to Na+ exposure. The radioimmunoassay demonstrated the cGMP level to rise after exposure to anti-immunoglobulin serum. The Na+-dependent Ca2+ efflux from the mitochondria might be the main mechanism in anti-immunoglobulin serum activation of B lymphocytes and in the cGMP level rising.
结果表明，抗免疫球蛋白血清激活的B淋巴细胞运动性在缺钠培养基和含10（-5）M三氟拉嗪的培养基中可能被消除，但在缺钙培养基中不会被消除。四环素荧光试验表明，由于钠的暴露，分离的B淋巴细胞线粒体中有钙离子外流。放射免疫测定表明，暴露于抗免疫球蛋白血清后，环磷酸鸟苷（cGMP）水平升高。线粒体中钠依赖性钙离子外流可能是抗免疫球蛋白血清激活B淋巴细胞和cGMP水平升高的主要机制。
