Ado A D, Dontsov V I
Biull Eksp Biol Med. 1984 Feb;97(2):177-8.
Study of the effects of acetylcholine, exogenous cGMP and Con A on the mobility of B lymphocytes has demonstrated that an increase in both the content of cGMP and calcium in B lymphocytes stimulates their mobility. The measurement of intracellular content of cGMP in B lymphocytes by radioimmunoassay has shown that this content changes rapidly in response to the action of acetylcholine and that it is dependent but negligibly on extracellular calcium. The dependence of the effects of all three substances on trifluoperazine, a calmodulin v blocker, indicates that stimulation of B lymphocyte mobility is ultimately determined by the calcium mechanisms.
对乙酰胆碱、外源性环鸟苷酸（cGMP）和刀豆球蛋白A（Con A）对B淋巴细胞迁移率影响的研究表明，B淋巴细胞中cGMP含量和钙含量的增加均会刺激其迁移。通过放射免疫测定法对B淋巴细胞中cGMP的细胞内含量进行测量，结果显示，该含量会因乙酰胆碱的作用而迅速变化，并且其依赖于细胞外钙，但程度可忽略不计。这三种物质的作用对钙调蛋白v阻断剂三氟拉嗪的依赖性表明，B淋巴细胞迁移率的刺激最终由钙机制决定。
