Federspil P
HNO. 1984 Oct;32(10):417-8.
In the introduction the main importance of the total dose of administered aminoglycoside antibiotics for ototoxicity is stressed. Within the clinical ototoxicity dose range fewer than 2% of the patients with no ototoxicity increasing factors are at risk of irreversible ototoxic damage. Within the absolute ototoxicity range this risk is less than 0.2%. On the basis of clinical and experimental experience of the different aminoglycoside antibiotics, the values for the clinical and absolute ototoxicity threshold doses of the modern aminoglycoside antibiotics are indicated. For gentamicin, these values amount to 50 and 20 mg/kg respectively and for amikacin to 120 and 50 mg/kg body weight respectively.
在引言中强调了氨基糖苷类抗生素给药总剂量对耳毒性的主要重要性。在临床耳毒性剂量范围内，没有耳毒性增加因素的患者中，发生不可逆耳毒性损害的风险低于2%。在绝对耳毒性范围内，这种风险小于0.2%。根据不同氨基糖苷类抗生素的临床和实验经验，给出了现代氨基糖苷类抗生素的临床和绝对耳毒性阈值剂量值。对于庆大霉素，这些值分别为50和20mg/kg，对于阿米卡星，分别为120和50mg/kg体重。
