Christiansen F T, Pollack M S, Garlepp M J, Dawkins R L
J Neuroimmunol. 1984 Dec;7(2-3):121-9. doi: 10.1016/s0165-5728(84)80012-0.
The association of HLA B8 and DR3 with generalised adult onset myasthenia gravis (GMG) in European Caucasoids is now well established. Studies of the HLA association with myasthenia gravis (MG) in other races might help to determine the location of a critical disease locus. Some previous studies in Japanese, Thais, Asian Indians and Filipinos have been reported. In this study HLA A, B, C and DR typing on 28 American blacks with either GMG or ocular myasthenia gravis (OMG) is reported. A significant increase in both HLA A1 and B8 was detected but there was an increase in DR5 rather than DR3. A review of the HLA antigen frequencies in other races and in D-penicillamine (D-Pen) induced MG suggests that prior claims implicating immune response genes marked by DR3 require review. It seems unlikely that any particular HLA allele is involved directly. Other possibly relevant combinations of alleles or supratypes are suggested. These may provide the basis for future studies of the immunogenetic basis for MG.
在欧洲白种人中，HLA B8和DR3与成人全身性重症肌无力（GMG）的关联现已得到充分证实。对其他种族中HLA与重症肌无力（MG）关联的研究可能有助于确定关键疾病基因座的位置。此前已有一些针对日本人、泰国人、亚洲印度人和菲律宾人的研究报道。在本研究中，报告了对28名患有GMG或眼肌型重症肌无力（OMG）的美国黑人进行的HLA A、B、C和DR分型。检测到HLA A1和B8均显著增加，但DR5增加而非DR3。对其他种族以及青霉胺（D-Pen）诱发的MG中的HLA抗原频率进行的综述表明，先前有关以DR3为标记的免疫反应基因的说法需要重新审视。似乎不太可能有任何特定的HLA等位基因直接参与其中。文中提出了其他可能相关的等位基因组合或超型。这些可能为未来MG免疫遗传学基础的研究提供依据。
