Joiner M C, Bremner J C, Denekamp J, Maughan R L
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Nov;46(5):625-38. doi: 10.1080/09553008414551811.
Mouse feet were irradiated with mixtures of 3 MeV neutrons and 140 kVp X-rays given simultaneously or within 24 hours of each other. The effects of different treatments were contrasted by comparing the doses required to give equal skin reactions. Irradiation was given as 1, 2, 4 or 8 equal fractions, in order to assess r.b.e. and the shapes of the underlying dose-response curves for mixed beams over a wide range of dose per fraction. All dose-effect curves were well fitted by a linear-quadratic (alpha, beta) model. For X-rays and neutrons given simultaneously, the linear coefficient (alpha) decreased by a factor of 4.80 while the quadratic coefficient (beta) increased by a factor of only 1.44 when the proton contamination in the beam increased from 11 to 100 per cent, with alpha/beta changing from 95.0 to 13.8. The data from simultaneous X-ray and neutron irradiation were consistent with full interaction of those effects from the two radiations which give rise to the total quadratic component of effect. When the two radiations are separated by up to 24 h, this interaction decreases but does not entirely disappear.
用3兆电子伏中子和140千伏峰值X射线的混合射线同时或在彼此24小时内照射小鼠足部。通过比较产生相同皮肤反应所需的剂量来对比不同治疗方法的效果。照射分为1、2、4或8个相等的分次进行，以便在每个分次的广泛剂量范围内评估相对生物效应（r.b.e.）以及混合射线潜在剂量反应曲线的形状。所有剂量效应曲线都能很好地用线性二次（α，β）模型拟合。对于同时给予的X射线和中子，当射线中的质子污染从11%增加到100%时，线性系数（α）降低了4.80倍，而二次系数（β）仅增加了1.44倍，α/β从95.0变为13.8。同时进行X射线和中子照射的数据与两种辐射产生总效应二次成分的那些效应的完全相互作用一致。当两种辐射间隔长达24小时时，这种相互作用会减弱但不会完全消失。
