[Effectiveness of the calcium antagonist nifedipine and the protease inhibitor with plasmin inactivating effect para-aminomethylbenzoic acid on stress-induced bronchial asthma].

In 15 asthmatics (7 females, 8 males, average age 23.3 years) the efficacy of the calcium antagonist nifedipine (Corinfar) and of PAMBA on the exercise-induced asthma was investigated. The patients underwent for 6 minutes a submaximal exercise (80 +/- 5% of the age-related maximum pulse rate) on the bicycle ergometer or by free running. Nifedipine exhibited a highly significant inhibition of the exercise-induced bronchial obstruction (p less than 0.001). Under the PAMBA-medication no significant differences could be stated in comparison to the exercise test without medicament (p greater than 0.5). A standardization of the exercise tests is to be aspired to.