Marín J M, León E, Pérez-Trullén A
Allergol Immunopathol (Madr). 1986 Jan-Feb;14(1):37-41.
The calcium entry blockers may inhibit EIA in patients with bronchial asthma, but it is not demonstrated that they produced bronchodilation once the crisis is established. Nine patients with exercise induced asthma were studied. We carried out an exercise test for ten minutes with constant load and the following were measured; FVC, PEF, MEF25 and sGaw before and after test. All the values fell 20% or more than the initial values. A 20 mg was administered without modifying the studied parameters and only the administration of 400 micrograms of metaproterenol by inhalation made the sensation of dyspnea recur in all patients.
钙通道阻滞剂可能会抑制支气管哮喘患者的运动诱发性哮喘（EIA），但并未证实它们在发作一旦确立后能产生支气管扩张作用。对9例运动诱发性哮喘患者进行了研究。我们以恒定负荷进行了10分钟的运动试验，并测量了试验前后的用力肺活量（FVC）、呼气峰值流速（PEF）、25%最大呼气流量（MEF25）和比气道传导率（sGaw）。所有数值均下降了20%或超过初始值。给予20毫克（药物），未改变所研究的参数，而仅通过吸入给予400微克间羟异丙肾上腺素就使所有患者再次出现呼吸困难的感觉。
