Trufanova L M, Belonosov S S, Rubtsova I I, Chel'tsov V V, Lepakhin V K, Moiseev V S
Ter Arkh. 1991;63(8):15-9.
In 13 patients with bronchial obstruction due to or enhanced by effort, the bronchodilatory effects of calcium antagonists (nifedipine and diltiazem) were studied and compared during the two-week treatment with each drug with a weekly interval. The appearance of bronchospasm at the 3d-5th minute after submaximal exercise (decrease of the volume of forced expiration during 1s by not less than 20% of the initial value) was regarded as a sign of asthma of effort. In 4 patients, bronchial obstruction in response to exercise was the only clinical sign of the disease, in 6 it was coupled with allergy, and in 3 patients, it aggravated the health status during exacerbation of bronchopulmonary infection. The patients were under observation during clinical remission of the disease. The clinical and instrumental data were estimated to reveal no well-defined correlation between the drugs. Both of them influenced bronchial patency, mainly at the level of the large and medium bronchi. Nifedipine was found to produce a more remarkable bronchodilatory effect.
在13例因用力导致或加重支气管阻塞的患者中，研究并比较了钙拮抗剂（硝苯地平和地尔硫䓬）的支气管扩张作用。在为期两周的治疗期间，每周使用一种药物，观察用药效果。次最大运动量运动后第3至5分钟出现支气管痉挛（1秒用力呼气量减少至初始值的20%以下）被视为运动性哮喘的征象。4例患者中，运动诱发的支气管阻塞是该病唯一的临床症状；6例伴有过敏；3例在支气管肺部感染加重时病情恶化。患者在疾病临床缓解期接受观察。临床和仪器检查数据显示，两种药物之间没有明确的相关性。二者均主要在大中支气管水平影响支气管通畅性。发现硝苯地平具有更显著的支气管扩张作用。
