Geyer H, Nothnagel D
Geburtshilfe Frauenheilkd. 1984 Dec;44(12):787-91. doi: 10.1055/s-2008-1036520.
Fibrin-fibrinogen degradation products and SP 1 were measured in about 150 women with normal pregnancies. The mean levels of both parameters rose up to term. In 13 normal pregnancies the SP 1 course never decreased. Elevated levels of SP 1 were measured in 4 out of 10 cases of mild gestosis. In 11 cases of severe gestosis, however, 7 had increased values. A decrease of elevated levels correlated to a clinical deterioration. SP 1 was normal in the most cases of severe gestosis, but a fall of SP 1 indicated an impaired placental function resulting in small-for-date baby or imminent foetal asphyxia. The measurements of fibrinogen degradation products and of the course of SP 1 are helpful in the diagnosis of gestosis.
对约150名正常妊娠女性进行了纤维蛋白-纤维蛋白原降解产物和SP 1检测。这两个参数的平均水平在足月时升高。在13例正常妊娠中，SP 1水平从未下降。10例轻度妊娠中毒症中有4例SP 1水平升高。然而，在11例重度妊娠中毒症中，7例值升高。升高水平的下降与临床病情恶化相关。在大多数重度妊娠中毒症病例中，SP 1正常，但SP 1下降表明胎盘功能受损，导致胎儿生长受限或即将发生胎儿窒息。纤维蛋白原降解产物和SP 1水平的检测有助于妊娠中毒症的诊断。
