谷胱甘肽耗竭会延长哺乳动物细胞中氧反应性自由基的寿命。
Glutathione depletion enhances the lifetime of oxygen-reactive radicals in mammalian cells.
作者信息
Hodgkiss R J, Jones N R, Watts M E, Woodcock M
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Dec;46(6):673-4. doi: 10.1080/09553008414551901.
PMID:6335495
Abstract
When the cellular glutathione content is reduced, adding oxygen (130 mumol dm-3) 7 ms after irradiation of hypoxic cells increases the radiosensitivity (factor approximately 1.25), whereas it has much less effect in normal cells.
摘要
当细胞内谷胱甘肽含量降低时，在对缺氧细胞进行照射后7毫秒添加氧气（130微摩尔/立方分米）会增加放射敏感性（系数约为1.25），而对正常细胞的影响则小得多。
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