Stevens R G, Kalkwarf D R
Pacific Northwest Laboratory, Richland, WA 99352.
Environ Health Perspect. 1990 Jul;87:291-300. doi: 10.1289/ehp.9087291.
Increased iron content of cells and tissue may increase the risk of cancer. In particular, high available iron status may increase the risk of a radiation-induced cancer. There are two possible mechanisms for this effect: iron can catalyze the production of oxygen radicals, and it may be a limiting nutrient to the growth and development of a transformed cell in vivo. Given the high available iron content of the western diet and the fact that the world is changing to the western model, it is important to determine if high iron increases the risk of cancer.
细胞和组织中铁含量的增加可能会增加患癌风险。特别是，高铁可利用状态可能会增加辐射诱发癌症的风险。这种效应有两种可能的机制：铁可以催化氧自由基的产生，并且它可能是体内转化细胞生长和发育的一种限制性营养素。鉴于西方饮食中铁的可利用含量较高，以及世界正逐渐向西方模式转变，确定高铁是否会增加患癌风险很重要。
