Syrjänen S M, Syrjänen K J
Scand J Dent Res. 1984 Dec;92(6):557-63. doi: 10.1111/j.1600-0722.1984.tb01297.x.
The labial salivary glands of 81 patients with rheumatoid arthritis (RA) and those of 45 control (CO) patients were biopsied. Mast cell counts were compared with the number of other inflammatory cells (B- and T-lymphocytes and mononuclear phagocytes, stained with acid-alpha-naphthyl acetate esterase technique (ANAE) and to fatty change and fibrosis. Mast cells were directly related to the amount of fibrosis and fatty change in both series, supporting the recent theory that these changes are age-related phenomena and not caused by RA per se. Mast cell counts increased slightly with increasing inflammatory cell infiltration, but no correlation could be found between mast cell counts and B or T cells. Mononuclear phagocyte system (MPS) cells were fewer in the RA group than in CO patients, possibly suggesting an impaired phagocytizing capacity in their salivary glands. In many respects the results are consistent with the known functions of tissue mast cells. Their role in the labial salivary glands is discussed in the light of current immunopathologic concepts of RA and lesions associated with it, i.e. Sjögren's syndrome.
对81例类风湿性关节炎（RA）患者和45例对照（CO）患者的唇唾液腺进行活检。将肥大细胞计数与其他炎症细胞（B淋巴细胞、T淋巴细胞和单核吞噬细胞，采用酸性α-萘乙酸酯酶技术（ANAE）染色）的数量以及脂肪变性和纤维化情况进行比较。在这两组中，肥大细胞均与纤维化和脂肪变性的程度直接相关，这支持了近期的理论，即这些变化是与年龄相关的现象，而非由RA本身引起。随着炎症细胞浸润增加，肥大细胞计数略有增加，但在肥大细胞计数与B细胞或T细胞之间未发现相关性。RA组的单核吞噬细胞系统（MPS）细胞比CO患者少，这可能表明其唾液腺的吞噬能力受损。在许多方面，结果与组织肥大细胞的已知功能一致。根据RA的当前免疫病理学概念及其相关病变即干燥综合征，讨论了它们在唇唾液腺中的作用。
