O'Brien T F, Acar J F, Medeiros A A, Norton R A, Goldstein F, Kent R L
JAMA. 1978 Apr 14;239(15):1518-23.
Prevalence of bacterial resistance to antibiotics was found to be substantially different in two separate regions of the world. The average percent resistant to individual antibiotics was nearly three times greater, and the percent of isolates resistant to six or more antibiotics 14 times greater among isolates at the Hôpital St Joseph in Paris than among those at the Peter Bent Brigham Hospital in Boston or at any of six US hospitals. Differences were not due to culture sampling or susceptibility testing methods used in the hospitals. Differences were nearly as great between isolates from patients recently admitted to the two hospitals, suggesting differences in the bacterial flora of their communities. Similar systematic comparisons of resistance prevalence in different parts of the world might help to define optimal antibiotic usage practices.
研究发现，世界上两个不同地区的细菌对抗生素的耐药率存在显著差异。巴黎圣约瑟夫医院分离株对个别抗生素的平均耐药百分比几乎是波士顿彼得·本特·布里格姆医院或美国六家医院中任何一家的近三倍，对六种或更多抗生素耐药的分离株百分比则是其14倍。差异并非源于医院使用的培养采样或药敏试验方法。两家医院近期入院患者的分离株之间差异也几乎同样大，这表明其所在社区的细菌菌群存在差异。对世界不同地区耐药率进行类似的系统比较，可能有助于确定最佳抗生素使用方法。
