Saxena R N, Pendse V K, Khanna N K
Indian J Physiol Pharmacol. 1984 Oct-Dec;28(4):299-305.
Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only. L-isoleucine also exhibited prolonged analgesic effect while DL-isoleucine had a short lasting effect. The amino-acids produced no gastric ulceration or overt acute toxicity in doses which effectively suppress inflammation. Anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.
口服给予的L-异亮氨酸、DL-异亮氨酸和L-亮氨酸在除甲醛诱导的炎症外的许多炎症测试模型中均表现出抗炎活性。L-β-苯丙氨酸仅抑制角叉菜胶诱导的水肿。L-异亮氨酸还表现出延长的镇痛作用，而DL-异亮氨酸的作用持续时间较短。这些氨基酸在有效抑制炎症的剂量下不会产生胃溃疡或明显的急性毒性。抗炎活性似乎与干扰前列腺素的作用和/或合成有关，值得进一步深入研究。
