Madan B R, Al-Motrefi A
Department of Pharmacology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Res Commun Chem Pathol Pharmacol. 1987 Dec;58(3):393-6.
L-leucinamide hydrochloride, an amino acid derivative, was found to share the ability of phenylbutazone in attenuating the phlogistic response induced by intraplantar injection of formaldehyde and nystatin in the unanesthetized rat. In the granuloma pouch induced by the injection of air and croton oil, chronic administration of the drug for 7 days resulted in significant reduction in the volume of exudate and the weight of granulation tissue. While the mechanism of anti-inflammatory action has not been elucidated, it seems that the pituitary-adrenal system is not involved since there was no change in the weight of the adrenals. Of interest is the finding that leucinamide, unlike phenylbutazone, failed to produce gastric ulcers in the effective anti-inflammatory doses.
L-亮氨酰胺盐酸盐是一种氨基酸衍生物，研究发现它与保泰松一样，具有减轻未麻醉大鼠足底注射甲醛和制霉菌素所诱导的炎症反应的能力。在空气和巴豆油注射诱导的肉芽肿袋实验中，连续7天长期给药可使渗出液体积和肉芽组织重量显著降低。虽然其抗炎作用机制尚未阐明，但由于肾上腺重量没有变化，似乎垂体-肾上腺系统未参与其中。有趣的是，与保泰松不同，亮氨酰胺在有效抗炎剂量下不会引起胃溃疡。
