Owoyele Bamidele V, Adebukola Olubori M, Funmilayo Adeoye A, Soladoye Ayodele O
Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria.
Inflammopharmacology. 2008 Aug;16(4):168-73. doi: 10.1007/s10787-008-7008-0.
The anti-inflammatory activity of an ethanolic extract of Carica papaya leaves was investigated in rats using carrageenan induced paw oedema, cotton pellet granuloma and formaldehyde induced arthritis models. Experimental animals received 25-200 mg/Kg (orally) of the extracts or saline (control group) and the reference group received 5 mg/ Kg of indomethacin. The ulcerogenic activity of the extract was also investigated. The results show that the extracts significantly (p <0.05) reduced paw oedema in the carrageenan test. Likewise the extract produced significant reduction in the amount of granuloma formed from 0.58 +/-0.07 to 0.22 +/-0.03 g. In the formaldehyde arthritis model, the extracts significantly reduced the persistent oedema from the 4th day to the 10th day of the investigation. The extracts also produced slight mucosal irritation at high doses. The study establishes the anti-inflammatory activity of Carica papaya leaves.
采用角叉菜胶诱导的爪肿胀、棉球肉芽肿和甲醛诱导的关节炎模型，在大鼠中研究了番木瓜叶乙醇提取物的抗炎活性。实验动物口服25 - 200 mg/Kg提取物或生理盐水（对照组），参考组接受5 mg/Kg吲哚美辛。还研究了该提取物的致溃疡活性。结果表明，在角叉菜胶试验中，提取物显著（p <0.05）减轻了爪肿胀。同样，提取物使形成的肉芽肿量从0.58±0.07 g显著减少至0.22±0.03 g。在甲醛关节炎模型中，从研究第4天到第10天，提取物显著减轻了持续性水肿。高剂量时，提取物也产生了轻微的粘膜刺激。该研究证实了番木瓜叶的抗炎活性。
